General: Caused by syphilis or, rarely, epidemic encephalitis; disseminated sclerosis; diabetes; brain tumor; syringomyelia; syringobulbia; chronic alcoholism; injury; encephalitis lethargic a, Guillain-Barré syndrome, Lyme disease, multiple sclerosis, polyarteritis nodosa, and sarcoidosis have been associated with this condition.
Ocular: No direct or consensual pupil reaction to light but to normal accommodation (except in terminal stages, when pupil is fixed to all stimuli); pupil contraction with eserine but poor dilation with atropine; miosis (generally); irregular pupil; occurs unilaterally and bilaterally; anisocoria or discoria frequent.
Clinical: Syphilis of central nervous system; general paresis; tabes dorsalis.
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