logo
Question of the Week
Video Library
Ophthalmology Books & Manuals
Cyber-Sight Atlas of Eye Diseases
The Ophthalmology Minute
Nursing Education
Eye Care Equipment
ORBIS Program Features
Free Online Journals
Ophthalmology Links
Ask a Professor
Print ViewPrint this Page
Lids : HYPERPIGMENTATION (DISCOLORATION OF LIDS)

MONGOLOID PALPEBRAL FISSURE  |  ANTIMONGOLOID PALPEBRAL FISSURE  |  PSEUDOPTOSIS  |  BLEPHAROPTOSIS  |  SYNDROMES AND DISEASES ASSOCIATED WITH PTOSIS  |  SPECIFIC BLEPHAROPTOSIS  |  HORNER SYNDROME  |  PTOSIS OF LOWER LID  |  LAGOPHTHALMOS  |  PSEUDO-LID RETRACTION  |  LID RETRACTION  |  LID LAG  |  BLEPHAROSPASM (SPASMODIC EYELID CLOSURE)  |  FACIAL PALSY  |  INFREQUENT BLINKING  |  FREQUENT BLINKING  |  LID EDEMA (PUFFINESS OR BAGGINESS OF LIDS)  |  BLEEDING OF THE EYELID  |  ECTROPION  |  ENTROPION (INVERSION OF LID MARGIN)  |  EPICANTHUS (FOLD OF SKIN OVER INNER CANTHUS OF EYE)  |  HYPOPIGMENTATION (DEPIGMENTATION OF EYELIDS)  |  HYPERPIGMENTATION (DISCOLORATION OF LIDS)  |  TUMORS OF EYELIDS  |  XANTHELASMA  |  CHRONIC BLEPHARITIS (INFLAMMATION OF LIDS)  |  ACUTE BLEPHARITIS  |  THICKENED EYELIDS  |  BLEPHAROPHIMOSIS (SHORT PALPEBRAL FISSURE)  |  EURYBLEPHARON  |  LID COLOBOMA  |  NECROSIS OF EYELIDS  |  POLIOSIS (WHITENING OF HAIR, EYEBROWS, AND EYELASHES)  |  TRICHOMEGALY (LONG LASHES)  |  MADAROSIS (LOSS OF EYELASHES)  |  DISTICHIASIS  |  COARSE EYEBROWS  |  SYNOPHRYS (CONFLUENT EYEBROWS EXTENDING TO MIDLINE)  |  HERTOGH SIGN (LACK OF OUTER THIRD OF EYEBROWS)  |  LID MYOKYMIA  |  PRESEPTAL CELLULITIS OF EYELID  |  TELECANTHUS  |  ANKYLOBLEPHARON  |  FLARING OF NASAL PART OF EYEBROW  |  HIGH ARCHED BROW  |  ABSENT BROW HAIR  |  TRICHIASIS (INWARD TURNING LASHES)

1. Deposits of the eyelids as caused by drugs, including:
2. Hyperpigmentation as caused by drugs, including the following:
 
acetophenazine
acid bismuth sodium tartrate
actinomycin C
Alcian blue
aluminum nicotinate
aminopterin
amiodarone
amodiaquine
amphotericin B
antipyrine
aurothioglucose
aurothioglycanide
bismuth oxychloride
bismuth sodium tartrate
bismuth sodium thioglycollate
bismuth sodium triglycollamate
bismuth sub salicylate chloroquine
bismuth subcarbonate
bleomycin
busulfan
butaperazine
calcitriol
carphenazine
chlorpromazine
chlortetracycline
chrysarobin
clofazimine
colloidal silver
cyclophosphamide
cytarabine
dactinomycin
demeclocycline
diethazine
doxycycline
dromostanolone
enalapril
epinephrine
ergocalciferol
ethopropazine
ferrocholinate
ferrous fumarate
ferrous gluconate
ferrous succinate
ferrous sulfate
floxuridine
fluorescein
fluorouracil
fluoxymesterone
fluphenazine
gold Au 198
gold sodium thiomalate
gold sodium thiosulfate
hydroxychloroquine
iron dextran
iron sorbitex
ketoprofen
mercaptopurine
mercuric oxide
mesoridazine
methacycline
methdilazine
methotrexate
methotrimeprazine
methylene blue
mild silver protein
minocycline
minoxidil
niacinamide
nicotinic acid
nicotinyl alcohol
nitromersol
oxytetracycline
penicillamine
perazine
pericyazine
perphenazine
phenylmercuric acetate
phenylmercuric nitrate
piperacetazine
pipobroman
polysaccharide-iron complex
practolol
procarbazine
prochlorperazine
promazine
promethazine
propiomazine
quinacrine
rifampin
rose bengal
silver nitrate
silver protein
sulfacetamide
sulfamethizole
sulfisoxazole
testolactone
testosterone
tetracycline
thiethylperazine
thimerosal
thimerosal thiopropazate
thioguanine
thioproperazine
thioridazine
trifluoperazine
triflupromazine
trimeprazine
uracil mustard
vitamin A
vitamin D2
vitamin D3

3. Periorbital hyperpigmentation-dark circles around the eye

 *A. Allergic rhinitis
 *B. Familial (autosomal dominant)
 C. Medium and dark complexioned white persons

4. Brown hyperpigmentation

 A. Genetic factors
  (1) Acanthosis nigricans
  (2) Albright syndrome (fibrous dysplasia)
  (3) Cafe-au-lait and freckle-like macules in neurofibromatosis
  (4) Dyskeratosis congenita
  (5) Fanconi syndrome (amino diabetes)
  (6) Freckles
  (7) Lentigines
  (8) Melanocytic nevus
  (9) Neurocutaneous melanosis
  (10) Seborrheic keratosis
  (11) Xeroderma pigmentosum
 B. Metabolic factors
  (1) Gaucher syndrome (cerebroside lipidosis)
  (2) Hemochromatosis
  (3) Niemann-Pick disease (essential lipoid histiocytosis)
  (4) Porphyria (cutanea tarda)
  (5) Wilson disease (hepatolenticular degeneration)
 C. Endocrine factors
  (1) adrenocorticotropic hormone (ACTH) therapy
  (2) Addison disease (adrenal cortical insufficiency)
  (3) Estrogen therapy
  (4) Melanoma
  (5) Pituitary tumors
  (6) Pregnancy
 D. Nutritional factors
  (1) Kwashiorkor (hypoproteinemia syndrome)
  (2) Pellagra (avitaminosis B2)
  (3) Sprue
  (4) Vitamin B12 deficiency (Addison pernicious anemia)
 E. Chemical and pharmacologic agents
  (1) Arsenic
  (2) Berlock dermatosis
  (3) Bleomycin
  (4) Busulfan
  (5) Nitrogen mustard, topical
  (6) Photochemical agents
 F. Physical agents
  (1) Ionizing radiation
  (2) Thermal radiation
  *(3) Trauma
  (4) Ultraviolet light
 G. Inflammation and infection
  (1) Atopic dermatitis
  (2) Lichen planus
  (3) Lichen simplex chronicus
  (4) Lupus erythematosus discoid (Kaposi-Libman-Sacks syndrome)
  (5) Psoriasis
  (6) Tinea versicolor
 H. Neoplasms
  (1) Acanthosis nigricans
  (2) Malignant melanoma
  (3) Mastocytosis
 I. Miscellaneous factors
  (1) Autosomal recessive ectodermal dysplasia
  (2) Catatonic schizophrenia
  (3) Chronic hepatic insufficiency
  (4) Cronkhite-Canada syndrome
  (5) Encephalitis
  (6) Erythema dyschromicum perstans
  (7) Liver spots
  (8) Systemic scleroderma (progressive systemic sclerosis)
  (9) Whipple syndrome (intestinal lipodystrophy)

5. Blue, gray or slate hyperpigmentation

 A. Genetic factors
  (1) Blue melanocytic nevus
  (2) Dermal melanocytosis (Mongolian spot)
  (3) Franceschetti-Jadassohn syndrome (reticular pigmented dermatosis)
  (4) Incontinentia pigmenti (Bloch-Sulzberger syndrome)
  (5) Oculodermal melanocytosis
 B. Metabolic factors
  (1) Amyloidosis, cutaneous macular (Lubarsch-Pick syndrome)
  (2) Hemochromatosis
 C. Nutritional factors
  (1) Chronic nutritional insufficiency
 D. Inflammation and infection
  (1) Erythema dyschromicum perstans
  (2) Pinta
  (3) Riehl melanosis
 E. Chemical and pharmacologic agents
  (1) Chlorpromazine
  (2) Gold
  (3) Phenothiazine
  (4) Sulfonamides
  (5) Tetracycline
 F. Neoplasms
  (1) Slate-gray dermal pigmentation with metastatic melanoma and     melanogenemia
 G. Other
  (1) Blue dye
  (2) Cyanosis

Fraunfelder FT, Fraunfelder FW. Drug-induced ocular side effects. Woburn, MA: Butterworth-Heinemann, 2001.

Haddock N, Wilkin JK. Periorbital hyperpigmentation. JAMA 1981; 246:835.

Pau H. Differential diagnosis of eye diseases, 2nd ed. New York: Thieme Medical, 1988.

Schwartz MP. Blue Christmas. JAMA 1987; 257:3229-3230.

footer logo