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Lacrimal Duct Defect to Lymphoid Hyperplasia -  

Lymphoid Hyperplasia
Lecture 52 of 52  NEXT»

(Reactive Lymphoid Hyperplasia; Lymphoid Tumors; Malignant Lymphoma; Pseudolymphoma; Pseudotumor; Burkitt Lymphoma; Neoplastic Angioendotheliomatosis)

General: Occurs in tropical Africa; young children; idiopathic orbital inflammation; systemic disease is rarely associated but occasionally occurs with either vasculitis or lymphomas; etiology of Burkitt lymphoma currently includes three factors: (i) Epstein-Barr virus, (ii) malaria, and (iii) chromosomal translocations activating the c-myc oncogene, which induces uncontrolled B-cell proliferation.
Ocular: Proptosis; extraocular motility disturbances; lesions of orbit, lacrimal gland, conjunctiva, and uvea; cortical blindness; retinal artery occlusion; retinal vascular and pigment epithelial alterations; vitreitis.
Clinical: Maxillary tumor; Epstein-Barr virus; cranial neuropathy.

Brooks HL, et al. Orbital Burkitt's lymphoma in a homosexual man with acquired immune deficiency. Arch Ophthalmol 1984; 102:1533-1537.
Cheung MK, et al. Diagnosis of reactive lymphoid hyperplasia by chorioretinal biopsy. Am J Ophthalmol 1994; 118: 457-462.
Liesegang TJ. Ocular adnexal lymphoproliferative lesions. Mayo Clin Proc 1993; 68:1003-1010.
de The G. The etiology of Burkitt's lymphoma and the history of the shaken dogmas. Blood Cells 1993; 19:667-673.
Donoso LA. Meningeal carcinomatosis secondary to malignant lymphoma (Burkitt's pattern). J Pediatr Ophthalmol Strabismus 1981; 18:48-50.
Elner VM, et al. Neoplastic angioendotheliomatosis. Ophthalmology 1986; 93:1237-1245.
Gaidano G, Dalla-Favera R. Biologic and molecular characterization of non-Hodgkin's lymphoma. Curr Opin Oncol 1993; 5:776-784.
Jakobiec FA, et al. Clinicopathologic characteristics of orbital lymphoid hyperplasia. Ophthalmology 1979; 86: 948-966.

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